Comparison of PB1-F2 Proximity Interactomes Reveals Functional Differences between a Human and an Avian Influenza VirusComparative Study Published on 2023-01-242023-06-22 Journal: Viruses [Category] 조류인플루엔자, [키워드] 14-3-3 proteins BioID2 host response Influenza virus interactome PB1-F2 virulence factor. [DOI] 10.3390/v15020328 PMC 바로가기 [Article Type] Comparative Study
The spectrum of clinical biomarkers in severe malaria and new avenues for explorationArticle Published on 2022-12-012022-11-15 Journal: Virulence [Category] 바이오마커, [키워드] Biomarker Biomarkers C-reactive protein clinical evaluation clinical infections Clinical practice complement COVID-19 pandemic diagnostic Endemic Evidence Factor faster highlight host response Infection infections malaria MOST non-specific omics technology pathogen patients Plasmodium Plasmodium falciparum Platelet Pneumonia practicality Prognosis prognostic Prognostic biomarkers Protein public health Research Sample size severe malaria the disease therapeutic therapeutic. [DOI] 10.1080/21505594.2022.2056966 PMC 바로가기
The human host response to monkeypox infection: a proteomic case series studyArticle Published on 2022-11-082022-11-16 Journal: EMBO Molecular Medicine [Category] 유전자 메커니즘, [키워드] acute phase response Applying Biomarker case sery CFHR1 complement correlation COVID-19 disease severity Diseases endemic area healthy controls Host host response human host Infection Monkeypox virus outbreak overlap Patient plasma plasma protein Protein Proteins proteome proteomic proteomics provided Research similarities suggested suppressed the disease viral infection Viral infection. [DOI] 10.15252/emmm.202216643 PMC 바로가기
Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronavirusesArticle Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] Analysis common cold Coronaviruses Compound COVID-19 COVID-19 therapeutics cytotoxicity effective gene expression profile globe Heat shock homoharringtonine host cell response host response in silico in vitro modulating other coronavirus pandemic pathway Prevent provided reported SARS-CoV-2 SARS-CoV-2 biology screened severe symptoms tanespimycin target tested unique Vaccine viral infection [DOI] 10.1038/s41598-022-21984-w PMC 바로가기
Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE studyArticle Published on 2022-11-012022-11-15 Journal: Angiogenesis [Category] 바이오마커, 유전자 메커니즘, [키워드] 28-day mortality adult COVID-19 patients Analysis Bacterial Bacterial sepsis Biomarker clinical outcomes Clinical severity Cluster Cohort conditions coronavirus disease Correlation analysis COVID-19 COVID-19 patient dimension disease disease entity dysfunction endothelial Endothelial dysfunction explained Health healthy control high mortality Hospitalized hospitals host response impairment independent intubation marker Microcirculation Microscopy Microvascular dysfunction microvascular injury outcome analysis outcomes overlap patients plasma plasma protein predict predictor Protein proteome proteomic Proteomic signature proteomics quantified sepsis. Variation was performed was used were measured were used [DOI] 10.1007/s10456-022-09843-8 PMC 바로가기
Vitamin D enhances type I IFN signaling in COVID-19 patientsArticle Published on 2022-10-222022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% confidence interval adjusted hazard ratio Admission all-cause mortality antimicrobial peptide Antiviral Antiviral effect antiviral response collected COVID-19 infection COVID-19 patient ENhance Host host response IFN in vitro intensive care interferon investigated ISGs JAK-STAT signaling pathway lower risk modulate on type outcome patient survival patients PBMC protein level Regulatory saliva specimen SARS-CoV-2 SARS-COV-2 infection severe COVID-19 patient Signaling significantly higher treated treated patient treated patients Treatment Type I IFN untreated patient Vitamin D Whole blood [DOI] 10.1038/s41598-022-22307-9 PMC 바로가기
Early suppression of antiviral host response and protocadherins by SARS-CoV-2 Spike protein in THP-1-derived macrophage-like cellsArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome Alpha Antiviral approved Cell cells cellular cellular response change coronavirus Coronavirus disease-19 COVID-19 cytokine differentially expressed downregulation Effect effort expressing expression highlight homeostasis host cells host response humoral immune responses induce Infection information interferon intrinsic involved medium pandemic pathogenic PROTECT Protein reflected Result S protein SARS-CoV-2 spike Spike protein the S protein transcriptomic transcriptomics transcriptomics. type I Vaccination strategies Vaccine variety while [DOI] 10.3389/fimmu.2022.999233 PMC 바로가기
Genetic variants determine intrafamilial variability of SARS-CoV-2 clinical outcomes in 19 Italian familiesArticle Published on 2022-10-132022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome addition Analysis association carried characterized clinical expression Clinical outcome clinical variability coronavirus COVID-19 determine disease genetic background genetic profile heterogeneity Host host response Immunity Infection Interaction involved Italian multifactorial occurred outcome performed Perspective phenotype positive protective effect rare variant risk SARS-CoV-2 shown SNPs statistical analysis statistically significant subject susceptibility the disease Transmission Transmission dynamics Vaccine Variability variant viral infection virus virus entry [DOI] 10.1371/journal.pone.0275988 PMC 바로가기
Histologic, viral, and molecular correlates of heart disease in fatal COVID-19Research article Published on 2022-10-012022-10-05 Journal: Annals of diagnostic pathology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] ACE2 expression activated arrhythmia Arrhythmias cardiac connexin 43 Control COVID-19 disease dysfunction edema endocytosed Endothelial cell evidenced experiment expression fatal COVID-19 greater heart heart tissue histologic host response IL6 immunohistochemistry In situ hybridization induce interstitial Macrophage manifestation Migration molecular multifocal myocarditis Myocardium Myocyte nucleocapsid protein obesity perivascular predominant Protein Proteins quantified risk RNA SARS-CoV-2 spike protein SARS-CoV2 severe COVID-19 sodium Spike protein the spike protein tissue TNFα Type II Diabetes unique Viral protein viral spike protein would increase [DOI] 10.1016/j.anndiagpath.2022.151983 [Article Type] Research article
A Review of Extracorporeal Blood Purification Techniques for the Treatment of Critically Ill Coronavirus Disease 2019 PatientsArticle Published on 2022-10-012022-11-15 Journal: ASAIO journal (American Society for Artificial Int [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory distress acute respiratory syndrome Antiviral apheresis Blood Blood purification caused characterized coronavirus coronavirus disease COVID-19 COVID-19 patients Critically ill Critically ill patient develop drug dysregulated immune response EBP Emergency use Extracorporeal extracorporeal blood purification food highlight host response Ill immune dysregulation Immunomodulatory therapies infected with SARS-CoV-2 Infection Multisystem organ failure novel Betacoronavirus Novel coronavirus outcome pandemic Patient reduce Respiratory illness review SARS-CoV-2 Seraph Spread syndrome System technique the disease the United State with COVID-19 World Health Organization Wuhan, China [DOI] 10.1097/MAT.0000000000001761 PMC 바로가기